Intimacy and Sexual Wellness: About the O-Shot (PRP)

Many women notice changes in desire, arousal, comfort or sensation at some point in life, for example after childbirth, around menopause, or during stressful times. Stress and responsibilities can also take a toll on intimate life. These concerns are common and worth discussing with a physician. One option some women ask about is the O-Shot, a procedure that uses platelet-rich plasma (PRP) made from your own blood. This page explains what it is, how it is done, and what the evidence does and does not show.

What Is the O-Shot?

The O-Shot is the name of a procedure in which platelet-rich plasma (PRP), prepared from a small sample of your own blood, is injected into specific areas of the vulva and vagina. Platelets contain growth factors that take part in the body's normal tissue repair. The idea behind the procedure is that these growth factors may support local tissue health, blood flow and sensitivity. Its aim is to support women's sexual wellness, such as arousal, sensation and comfort.

How the Procedure Is Done

1. Consultation: Your physician reviews your symptoms, health history and medicines, and checks whether other causes should be looked at first.
2. Blood draw: A small amount of blood is taken from your arm, much like a routine blood test.
3. Preparation: The blood is spun in a centrifuge to separate and concentrate the platelet-rich plasma.
4. Numbing: A numbing cream is applied to the area to help keep you comfortable.
5. Injection: The PRP is injected into the targeted areas with a fine needle. The procedure is done in the office, and your physician will explain what to expect afterward.

What Does the Evidence Show?

Research on PRP for women's sexual wellness is still limited. Studies so far have been small, many did not compare PRP with a placebo, and results have been mixed. Some women report changes in arousal, sensation or comfort, while others notice little or no difference. Using PRP for sexual wellness is an off-label use and is not FDA-approved for this purpose. Results vary from person to person, and the O-Shot is one option among several; no specific result is promised.

Possible Side Effects

Because PRP is made from your own blood, allergic reactions are unlikely. Possible side effects include temporary soreness, bruising, swelling, spotting or discomfort at the injection sites and, rarely, infection. PRP may not be suitable if you are pregnant, have an active infection, a bleeding or platelet disorder, or certain cancers. Tell your physician about all the medicines you take, including blood thinners.

Supportive and adjunctive care alongside conventional medical treatment.

Other Factors in Sexual Wellness

Sexual wellness is connected to overall health, hormones, mood, stress and relationships. Vaginal dryness or pain during sex, for example, is often related to lower estrogen around menopause, and there are several ways to address it. Low desire can be linked to medicines, poor sleep, stress, depression or relationship concerns. Pelvic floor problems and infections can also play a part. A careful evaluation helps make sure the right concerns are addressed.

Who to Ask

If you are considering the O-Shot or PRP, talk with a physician who can review your history, explain the possible benefits, risks and costs, and discuss alternatives. Dr. Dalal Akoury, MD, MPH, takes a personalized, whole-person approach to care, with attention to emotional and relational well-being as well as physical health.

To learn more, read about Regenerative Medicine and BHRT for women, or book a consultation to discuss whether PRP is right for you.

Related reading: PRP therapy: how platelet-rich plasma is used.